S100A8 and cancer: In contrast, S100A8 treatment decreased percentage of NK cells and their absolute numbers in lungs of mice with LLC cancers (CD3-/NK1.1+) (12.6 ± 1.0% to 6.7 ± 0.5%, p < 0.001); no change was observed in the spleen (Figure 6E and Supplementary Table 3).