S100A8 and cancer: Concurrently, S100A8 significantly decreased protein levels of IL-4 (381.0 ± 66.6 pg/mL to 194.3 ± 34.2 pg/mL, p < 0.05) and IFN-γ (121.5 ± 16.5 pg/mL to 22.1 ± 5.5 pg/mL, p < 0.0001) in BALF from mice with LLC cancers to basal levels (Figures 3C, D).