Because NK cells infiltrating lung cancers tend to be non-functional and lack cancer-killing activity (42–44), and given that S100A8 treatment reduced percentage of NK cells, but increased percentage of NK-T cells in lungs (Figures 6C, E), we next asked whether S100A8 may suppress infiltration of non-functional NK cells and enhance NK cell function. This evidence concerns the gene S100A8 and lung carcinoma.