Next, we tested whether S100A8 treatment alone altered lymphocyte infiltration and found significantly increased percentage of total T cells (CD3+) (21.7 ± 2.9% to 34.4 ± 1.3%, p < 0.001) and their absolute numbers in lungs, but not in spleen, of cancer-bearing mice compared to controls (Figure 6A and Supplementary Table 3). This evidence concerns the gene S100A8 and cancer.