The overexpression of NF-κβ and its correlations with remodeling factors in cholesteatoma proves that disbalance between MMPs and TIMPs affects NF-κβ and causes uncontrolled cell proliferation and immune response in this tumor.There is a lack of strong VEGF expression in cholesteatoma perimatrix, indicating the absence of its importance in the pathogenesis of cholesteatoma. The gene discussed is NFKB1; the disease is neoplasm.