Resultingly, though induction of HO-1 has been a potential therapeutic target in kidney diseases, attention must be paid to the safe range of HO-1 induction, owing to the pro-ferroptotic role of HO-1 in raising intracellular ferrous load and redox homeostasis (Chang et al., 2018; Li R. et al., 2020; Fernández-Mendívil et al., 2021). The gene discussed is HMOX1; the disease is kidney disorder.