HO-1 induction could protect the kidney from oxidative stress showing anti-inflammatory and anti-apoptotic activity in DN (Abo El Gheit and Emam, 2016), which was also proved to reduce glomerular sclerosis and intimal hyperplasia, being a therapeutic target to improve the long-term outcomes after kidney transplantation (Bedard et al., 2005; Corona et al., 2020). The gene discussed is HMOX1; the disease is liver dysplastic nodule.