CDH1 and neoplasm: EMT, charactered by loss of E-cadherin, can facilitate ferroptosis, and upregulate transcription factors, including SNAI1, ZEB1, and, TWIST1, inducing EMT-mediated tumor metastasis, elevates ferroptosis sensitivity in turn (Wu et al., 2019), while E-cadherin-mediated cell-cell contacts has been demonstrated to protect against ferroptosis (Yang W.-H.