In this regard, the MAGL inhibitor JZL184 produced anxiolytic-like effects in rodents mainly under heightened stress conditions (e.g., brightly lit environments, following restraint stress).165,168,171–174 Unlike the anxiolytic effects of FAAH inhibitors that are strongly associated with CB1 receptor signaling,144 both CB1 and CB2 receptors have been implicated in the anxiety-reducing properties of MAGL inhibitors;173–176 to date, however, the preponderance of evidence suggests a CB1 receptor contingency. This evidence concerns the gene MGLL and Anxiety.