DAGLA and Anxiety: For example, DAGL-alpha knockout mice exhibit increased anxiety-like behaviors relative to their wild-type littermates,185,186 and these effects were reversed by the administration of JZL184.185 In the same regard, the DAGL inhibitor DO34 produced anxiogenic-like effects,187 although the extent to which prior stress conditions may differentially influence the expression of anxiety-like behavior remains to be elucidated.