Engagement of tumoral MHC-II with LAG-3 on T-cells was reported to protect melanoma cells from apoptosis.37 To ascertain the biological significance of MHC-II expression on PDAC cells, we first analyzed the effect of the engagement of MHC class II molecules on Fas-induced cell death using the PDAC cell line SUIT-2 untreated (MHC II-negative) or treated with IFN-γ (MHC-II-positive). This evidence concerns the gene IFNG and melanoma.