Thus, the risk of diabetic eye disease increases by 7.29 times among patients treated with a combination of OHAs and insulin (95% CI: 2.07-25.61; p=0.002), by 7.34 times among patients treated only with insulin (95% CI: 2.14-25.11; p=0.001), and by 6.33 times among patients treated only with OHAs (95% CI: 1.90-21.05; p=0.003) (Table 6). Here, INS is linked to diabetic eye disease.