RUNX1 and hypertensive disorder: Figures 4E,F show the pathways that are jointly upregulated and downregulated in hypertension and IA, respectively. Finally, cross-tabulation analysis revealed that five GOIs, including IFI30, SERPINE1, HMOX1, IL24, and RUNX1, were found to be associated with hypertension, IA, and monocytes/macrophages (Figure 4G). And the differential expression of IFI30, SERPINE1, HMOX1, IL24, and RUNX1 were shown in the volcano plot (Figures 4A,B).