Figures 4E,F show the pathways that are jointly upregulated and downregulated in hypertension and IA, respectively. Finally, cross-tabulation analysis revealed that five GOIs, including IFI30, SERPINE1, HMOX1, IL24, and RUNX1, were found to be associated with hypertension, IA, and monocytes/macrophages (Figure 4G). And the differential expression of IFI30, SERPINE1, HMOX1, IL24, and RUNX1 were shown in the volcano plot (Figures 4A,B). This evidence concerns the gene SERPINE1 and hypertensive disorder.