Moreover, it revealed that in samples with upregulated RUNX1 expression, nonalcoholic fatty liver disease, oxidative phosphorylation, RUNX1 regulates the transcription of genes involved in the differentiation of HSCs and those involved in megakaryocyte differentiation, and platelet function pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function. The gene discussed is RUNX1; the disease is metabolic dysfunction-associated steatotic liver disease.