Along with ERK1/2 cascade, the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is responsive to cellular signals such as cytokines, growth factors, and hormones and also plays an implicated role in mediating of cardiac pathophysiological processes including hypertrophy, apoptosis, oxidative stress, myocardial interstitial fibrosis, and myocardial infarction signaling (6-9). The gene discussed is SOAT1; the disease is myocardial infarction.