TNF and neoplasm: Several tumor-related pathways were also regulated by these compounds inducing antiproliferative, death induction, decreased migration, or other phenotypes such as the oncogenic proteins JNK, Ras/MAPK, ERK1/2, p38, and PI3K; tumor suppressor proteins such as p53 and Chk1/2; and CDC25 and inflammation-related NF-κB, TNF-α, IL1-β, COX2, and iNOS.