Among patients with HCC in phase 1/2 of single agent, for which FGF19 IHC analysis was performed, 27 were FGF19 positive and 33 were FGF19 negative with a trend for better response among the FGF19 IHC-positive patients (Supplementary Fig. 2C, D). Here, FGF19 is linked to hepatocellular carcinoma.