Consistent with the FGF19/FGFR4 downstream pathway, tumor PD assessed by RNAseq revealed an upregulation of CYP7A1 transcript concomitant with downregulation of the MAPK target gene DUSP6, in most on-treatment biopsies obtained at C1D8 with respect to the matched pretreatment sample (Supplementary Fig. 3C, D). This evidence concerns the gene FGFR4 and neoplasm.