Although fibroblast transition to a cancer-associated fibroblast (CAF)-like phenotype was inhibited by targeting both RAGE and integrin-mediated mechano-transduction that in turn resulted in the reduction of FAK activation and YAP nuclear localization [25], the functional connection of RAGE with FAK/Hippo/YAP pathway in TNBC is still poorly understood. The gene discussed is AGER; the disease is cancer.