Moreover, we have also identified the main significant up-regulated Hippo-TFs in BC patients harboring high RAGE expression levels and, among the downstream target genes up-regulated by the canonical YAP interactors TEAD2 and TEAD4 Hippo TF family members, we have detected FLNA as the pivotal downstream gene correlated to extracellular matrix or cytoskeleton-related pathways leading to cancer cell invasive features. The gene discussed is AGER; the disease is cancer.