Considering that FLNA was identified among the top up-regulated genes by TEAD2/TEAD4 Hippo pathway transcription factors in the high RAGE expression BC cohort (See Fig. 4), we sought to assess whether S100A8/A9-RAGE-FAK signaling along with YAP can regulate the expression of FLNA in TNBC cells. The gene discussed is FLNA; the disease is breast cancer.