Patients have mostly established RA [median disease duration 5 years (min 0.5, max 51; IQR 9 years)], half of them were seropositive for rheumatoid factor (RF) or anti-CCP antibodies (ACPA) and received rituximab as the third (median) bDMARD treatment (min = 1, max = 7) (Table 1). The gene discussed is PRTN3; the disease is rheumatoid arthritis.