Pharmacologic induction of mitophagy, such as with the use of urolithin A, actinonin, or nicotinamide mononucleotide, has beneficial effects on Aβ and Tau pathologies and improves cognitive dysfunction in various AD models, including iPSC-derived neurons, transgenic nematodes, and AD mouse models [11]. The gene discussed is MAPT; the disease is Alzheimer disease.