Thus, the physically interaction of STAT3 and SMAD3 can attenuate the process of EMT, our data indicated that the interaction of STAT3 and SMAD3 could not be observed in HCC cells, and DYRK1A overexpression did not affect the interaction of STAT3 and SMAD3 in HCC cells. Here, SMAD3 is linked to hepatocellular carcinoma.