ADIPOQ and COVID-19: Furthermore, this pattern induces chronic activation of the innate immune system, produces pro-inflammatory mediators, increases oxidative stress and impairs T and B cell function in the adaptive immune system; while T and B cell counts were significantly lower in patients with severe COVID-19 patients [21]; also, it was reported that high fat diets, rich in saturated fat, reduce the levels of adiponectin, while diets high in poly-unsaturated fatty acids increase adiponectin levels and reducing pro-inflammatory cytokines [23].