To further confirm the role of circ_0004585 overexpression in PCa cells autophagic activation, anoikis resistance, and metastasis, the autophagic activator, rapamycin (Rapa), or the autophagic inhibitors, chloroquine (CQ) and 3-Methyladenine (3-MA), were added to PCa cells displaying stable circ_0004585 overexpression. The gene discussed is TRERF1; the disease is posterior cortical atrophy.