In addition, the TM9SF4 knockdown and overexpressed miR-1248 plasmids in the PCa cells were subjected to further co-transfection, revealing that the upregulated miR-1248 inhibition of the mTOR pathway was significantly reversed by TM9SF4 knockdown (Fig. 6C). The gene discussed is TM9SF4; the disease is posterior cortical atrophy.