Abnormalities in the phosphatidylinositol 3-kinase/serine-threonine kinase (PI3K/AKT) signaling pathway are strongly associated with tumor growth, maintenance, and chemotherapeutic resistance [28], which exhibits hyperactivation in HCC, and thereby promotes cell proliferation and invasion in cancers [29]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.