Differential gene expression (controlling for tumour grade) between ARNT-amplified versus samples wild-type for ARNT revealed downregulation of three interleukin receptors (limma based p.adj value for IL7R = 3.04 × 10e−02, IL21R = 3.95 × 10e−02 and for IL12RB2 = 2.03 × 10e−02) in ARNT-amplified NMIBCs (Additional file 1: Table S7). The gene discussed is IL12RB2; the disease is neoplasm.