We have recently reported that some inhibitory ICs, including programmed cell death-1 (PD-1), cytotoxic T lymphocyte-associated antigen (CTLA-4), T cell immunoglobulin and mucin domain-containing protein-3 (TIM-3), and lymphocyte-activation gene-3 (LAG-3), are expressed on CD4+ T cells and play roles in CRC progression [8]. The gene discussed is HAVCR2; the disease is colorectal carcinoma.