On the other hand, high frequencies of CD4+TIM-3+, FoxP3+Helios+TIM-3+ Tregs and FoxP3−Helios+TIM-3+ T cells in circulation are associated with longer DFS in CRC patients, suggesting that T cells expressing TIM-3 could be activated cells with improved anti-tumor activities. This evidence concerns the gene IKZF2 and colorectal carcinoma.