Furthermore, the LINE-1 methylation levels of AD (72.8 ± 4.4%) and CRC (71.2 ± 6.8%) tissue samples decreased significantly compared to their matched NAT pairs (76.0 ± 2.1%, 76.4 ± 2.0%, respectively) (p ≤ 0.05) (Additional file 2/B). This evidence concerns the gene BRD2 and Alzheimer disease.