MYCN and neuroblastoma: In contrast, SESN1 expression was downregulated in paediatric neuroblastoma patients with MYCN amplification in the TARGET, E-MTAB-161, E-MTAB-1781, E-MTAB-8248, E-TABM-38, GSE16476, GSE49710 and GSE85047 independent paediatric neuroblastoma cohorts (Fig. 4c).