Consistent with the previous results that overexpression of SESN1 was a favourable prognostic factor of paediatric neuroblastoma, the expression levels of SESN1 were lower in paediatric neuroblastoma patients with an age at diagnosis ≥ 18 months in the TARGET, E-MTAB-161, E-MTAB-1781, E-MTAB-8248, E-TABM-38, GSE16476, GSE49710 and GSE85047 datasets (Fig. 7a). This evidence concerns the gene SESN1 and neuroblastoma.