As shown in Table 4, the logistic model revealed that Nogo-B levels were independently associated with hypertension (OR = 1.007, 95%CI: 1.004–1.010, P < 0.01) after adjust for age, sex, BMI, history of smoking, alcohol consumption, and TC, TG, HDL, and LDL. This evidence concerns the gene RTN4 and hypertensive disorder.