We perform the ssGSEA enrichment analysis to explore the differences in activated immune cell infiltration and immune functions between subgroups (Fig. 9A,B), and the correlation between gene signature and infiltrated immune cell was presented in Fig. 9C. It can be concluded that low-risk group had more immune cell infiltration, especially CD8 T cell, NK cells, and helper T cells which were abundant in tumor microenvironment and important for the induction of immune activities. The gene discussed is CD8A; the disease is neoplasm.