We also evaluated the expression of TNF-RII on EVs, whose expression has been linked to tolerogenic immune reactions, including a subset of T-regulatory cells38 and IL-10-producing B cells39; and EVs expressing IL-6Rα, which is of high interest since our previous work has shown that IL-6 has prognostic value as an indicator of subsequent response to AIDS-NHL treatment and survival16. Here, IL10 is linked to non-Hodgkin lymphoma.