AIDS-NHL patients showed decreased plasma levels of EVs bearing PD-L1 (p = 0.006), CD40 (p = 0.003), CD40L (p < 0.001) or TNF-RII (p = 0.015) after cancer treatment, compared to baseline plasma levels (Wilcoxon signed rank test) (Fig. 2A–D). This evidence concerns the gene CD40LG and cancer.