In analyses stratified by T2DM, visually significant differences were also observed for factors 1, 2, 4, 5 and 8, with change in factor levels showing a stronger correlation with change in NT-proBNP in non-T2DM versus T2DM for factors 1, 2, 4 and 8; and a stronger correlation in T2DM versus non-T2DM for factor 5. The gene discussed is NPPB; the disease is type 2 diabetes mellitus.