We also found that increases in a factor comprised of the urea cycle intermediates, citrulline and ornithine, the amino acid proline, and the short-chain dicarboxylacylcarntine [SCDA] C5-DC were associated with decreases in 90-day NT pro-BNP, an association that was stronger in individuals without T2DM. Here, NPPB is linked to type 2 diabetes mellitus.