IL10 and Autoimmunity: There is also evidence that the HLA can influence the production of IgG4: distinct HLA variants were shown to determine the immune response towards autoimmunity or tolerance in animal models24,25 by directly affecting T-cell fate towards conventional (Tconv) or regulatory T cells (Tregs), and production of pro- or anti-inflammatory cytokines, including interleukin-10 (IL-10).