While we could confirm the positive association with HLA-DRB1*14, HLA-DQB1*05 and the HLA-DRB1*14-DQB1*05 haplotype after exclusion of pemphigus patients (Fig. S5–S7), the frequency of HLA-DRB1*04 (Fig. S3) was significantly decreased, suggesting this association is specific for pemphigus. This evidence concerns the gene HLA-DQB1 and pemphigus.