While some have been implicated in liver disease confirming previously published findings, such as C7 (ref. 50), LGALS3BP51, TGFBI52, ALDOB21, AFM21,53, TTR54, QSOX1 (ref. 52), F2 (ref. 52), APOF55, LBP56 and SERPINC1 (ref. 57), several have the potential to serve as new circulating biomarkers, including ASAP1, CLEC3B, CFH, ITIH4, ATRN, PEPD and SERPINF1. The gene discussed is QSOX1; the disease is liver disorder.