LMNA and Hutchinson-Gilford progeria syndrome: Detailed characterization of the humanized HGPS mouse model has shown that postnatal expression of progerin, under the regulation of the Krt5 promotor, results in a progressive skin phenotype which is characterized by epidermal hypoplasia, resting hair follicles, associated hypoplastic sebaceous glands, loss of hypodermis and a fibrotic dermis, similar to what is seen in HGPS patients and suggesting that this is a useful model for studying HGPS33.