Our analysis of VEGF and CXCL12 levels in tumours from Atf4WT/WT and Atf4Δ/Δ mice revealed that the levels of these cytokines were decreased in the perivascular areas of tumours grown in Atf4Δ/Δ mice, and vCAFs appear to be the main source of angiogenic factors in the perivascular areas. The gene discussed is CXCL12; the disease is neoplasm.