ACTA2 and pancreatic neoplasm: COL1A1, COL1A2, ACTA2, PDGFRB and FAP displayed a significant positive correlation with this gene dataset in melanoma tumours (SKCM), whereas in pancreatic tumours (PAAD), that correlation was even stronger owing to their highly desmoplastic TME (Fig. 7a and Extended Data Fig. 9a).