CD8A and neoplasm: Although there was a decrease in the total number of T cells and natural killer cells (T/NK cells) in Atf4Δ/Δ grown tumours, anti-CD8 treatment caused a small increase in the rate of tumour growth in both Atf4WT/WT and Atf4Δ/Δ mice, which suggests that other mechanisms must account for the dramatic differences seen between these cohorts (Extended Data Fig. 2h).