Moreover, epithelial CD1a + cells may interact with dendritic cells or T cells in the development of BE28.Fatty acid binding protein 4 (FABP4), predominantly expressed in adipocytes and macrophages, is associated with the development and progression of various kinds of tumors29.FABP4 may have a potential associations with hyperlipidemia, hyperinsulinemia, and insulin resistance, indirectly affecting cancer cells by influencing these factors30. This evidence concerns the gene FABP4 and hyperinsulinism.