Interestingly, there was one Skin-Melanoma sample having four different missense mutations and 2 different 3′-UTR piSNVs of PREX2, who had higher levels of malignancy (IV, AJCC 7th Edition 2010), while other samples normally had simply one missense mutation or 3′-UTR piSNV. Here, PREX2 is linked to melanoma.