PREX2 had the second highest 3′-UTR-length corrected frequency of 3’-UTR piSNV occurrence, and 9 of 2413 cancer patients were also identified to carry protein damaging mutations of PREX2; Thus, the 3′-UTR piSNV-affected genes were able to promote carcinogenesis at both the protein function and posttranscriptional regulation levels. Here, PREX2 is linked to cancer.