In the RBP immunoprecipitation assay, RBM47 specifically bound the 3′-UTR of type I IFN receptor IFNAR1 mRNA, stabilized the mRNA, and subsequently increased the protein level of intracellular IFNAR1, promoted viral infection or interferon-induced phosphorylation of STAT1/2, enhanced interferon-stimulated expression of gene ISGs and amplified the antiviral effect of the host77. The gene discussed is IFNAR1; the disease is viral infectious disease.