However, compared to Y79-CR cells, the anticancer activity of ferroptosis inducers (erastin, RSL3, and FIN56) was reduced in the parent Y79 cells and in another well-characterized human RB cell line, WERI-Rb-1 (Fig. 2H), highlighting a relatively selective role in the induction of ferroptosis to eliminate drug-resistant RB cells. This evidence concerns the gene RB1 and retinoblastoma.