COL18A1 and hereditary angioedema: Median age at diagnosis (31.1 vs. 40.9 years; p = 0.1276) and the median time between symptom onset and diagnosis (15.0 vs. 23.8 years; p = 0.6680) were numerically lower in patients with HAE-1/2 than in those with HAE nC1-INH, respectively, but differences were not statistically significant.