As shown in Figure 6, rapamycin pretreatment significantly inhibited MCAO/R-mediated upregulation of Sec22b and downregulation of Ykt6, suggesting that autophagy induction under physiological conditions before stroke may have the potential to indirectly regulate the expression of autophagosome transporters and promote the integrity of autophagic flux. The gene discussed is SEC22B; the disease is Stroke.