NFKB1 and rheumatoid arthritis: In this study, the effects of plumbagin on the viability, inflammatory cytokines, MMPs and nuclear factor kappa-B (NF-κB) pathway of IL-1β-induced HFLS-RAs and RA-modeled mice were determined, with the evaluation on the clinical scores and histopathological changes of ankle joint of RA-modeled mice.