The resulting 2-PAM@Zr-MOP-1(0) host–guestassemblies feature a sustained delivery of 2-PAM under simulated biologicalconditions, with a concomitant reactivation of DIFP-inhibited AChE.Finally, 2-PAM@Zr-MOP systems have been incorporatedinto biocompatible phosphatidylcholine liposomes with the resultingassemblies being non-neurotoxic, as proven using neuroblastoma cellviability assays. Here, ACHE is linked to neuroblastoma.