The luminal WT p53 derived MCF‐7 breast cancer cell line displayed a NED phenotype after SASP treatment, whereas MCF‐7 cells depleted in p53, the luminal p53 mutant T47D or the triple negative p53 mutant MDA‐MB‐231 breast cancer cells displayed impaired or no NED phenotype. This evidence concerns the gene TP53 and breast cancer.