CP and female infertility: To corroborate the conclusion that hemizygote zpgD/zpgS female infertility is the result of homing in the germline, and to understand how zpgD would interact with other gene drive elements, we generated transhemizygous females carrying zpgD in combination with a zpgR allele, as well as the previously characterized non-autonomous payload drive ScoGFP-CP, which harbours a gRNA targeting the CP wild-type allele but lacks Cas9 [43].