To address the need for a preclinical model of GBM that more closely recapitulates the human tumor immune microenvironment, we characterized our immunocompetent murine spontaneous GBM model (9), which harbors deletion of 3 common tumor suppressor genes in human gliomas: quaking (Qk in mice and QKI in humans) (10), Trp53 (11), and Pten (11). This evidence concerns the gene QKI and central nervous system cancer.