By examining the expression of such genes across PNPi/dG-sensitive T-ALL versus resistant B-ALL models, we observed that the deoxyribonucleotide triphosphohydrolase SAMHD1 was expressed at low levels in the majority of cancer cell line encyclopedia–annotated (CCLE-annotated) T-ALL lines relative to B-ALL lines (Figure 1D and Supplemental Figure 1F) (19). The gene discussed is SAMHD1; the disease is acute lymphoblastic leukemia.