Our study addresses this gap by first using MPM to identify keratinocyte mitochondrial changes in stable vitiligo patients and then corroborating these findings with scRNA-Seq to demonstrate that specific basal and parabasal keratinocyte states exhibit increased OxPhos and communicate with T cells via the CXCL9/ CXCL10/CXCR3 axis and exhibit decreased WNT signaling to melanocytes. The gene discussed is CXCL9; the disease is vitiligo.