DCEM1 treatment also inhibited mTOR signaling in PCa cells, as evidenced by decreased phosphorylation at residue Ser2448 of mTOR, Ser371 and Thr389 of p70 S6, and Thr37/46 of 4E-BP1 (Figure 8J). This evidence concerns the gene EIF4EBP1 and posterior cortical atrophy.