CLPP and posterior cortical atrophy: Notably, silencing of Hsp60 or ClpP (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI149906DS1) in PCa cells did not affect expression of LONP1, another mitochondrial matrix–localized ATP-dependent AAA+ protease and a critical factor in mtHSP70 folding machinery (16).