Similar to the c-Myc and EZH2 downregulation when HSP60 or ClpP was silenced or knocked out (Supplemental Figure 7, B–D, and Figure 5J), DCEM1 also robustly downregulated c-Myc and EZH2, and surprisingly, reduced AR and inhibited AR activity (as measured by prostate-specific antigen [PSA] levels) in PCa cells (Figure 7, I and J, Supplemental Figure 10E, and Supplemental Figure 13, A and C). This evidence concerns the gene CLPP and posterior cortical atrophy.