Interestingly, DCEM1 treatment did not alter the protein levels of UPRmt components, including HSP60, HSP10, ClpP, and LONP1 in most of the PCa cells and normal prostate epithelial cells, and in human embryonic HEK-293 cells (Supplemental Figure 10D and Supplemental Figure 12, A and B), although ClpP and LONP1 expression in PC-3 cells slightly decreased upon DCEM1 treatment (Supplemental Figure 12A). Here, HSPE1 is linked to posterior cortical atrophy.