PARL and posterior cortical atrophy: However, overexpression of inner mitochondrial membrane–localized protease PARL (61) did not show any effect on DCEM1-induced accumulation of poly-Ub proteins and DEVDase activity in PCa cells (Supplemental Figure 15B), suggesting that mitochondrial compartment–specific localization of proteases also plays a role in maintaining mitochondrial proteostasis and functions.