ANGPTL4 and age-related macular degeneration: Although we did not observe a correlation between the size of CNV lesions in AMD patients and the aqueous fluid levels of ANGPTL4, as has previously been reported (64), levels of ANGPTL4 remained increased in the aqueous fluid of patients with nvAMD being treated for active CNV compared with control patients without AMD, or patients with nnvAMD.