To further characterize the expression of ANGPTL4 in patients with nvAMD being treated in the clinic for active CNV, we obtained aqueous fluid samples from untreated, newly diagnosed patients with nvAMD (nvAMD UnTx) who were initiating treatment with anti-VEGF therapy and examined the levels of ANGPTL4 compared with aqueous fluid samples obtained prior to the initiation of cataract surgery from patients without AMD (Control) and patients with nonneovascular AMD (nnvAMD), or “dry” AMD (Supplemental Table 3). Here, VEGFA is linked to age-related macular degeneration.