SPINK5 and ichthyosis: Notably, the KLK7-ABP rescued major disease hallmarks, when applied onto the epidermis of Spink5−/−Klk5−/− mice.3Spink5−/− mice represent an established preclinical model that recapitulates the overdesquamating and inflammatory skin disease named Netherton syndrome, a rare ichthyosis caused by inactivating mutations in SPINK5 encoding the LEKTI inhibitor of serine proteases.