Knockout (KO) mice lacking the m6A writer (Metll3) (Xu et al. 2017; Yang et al. 2017), eraser (Alkbh5) (Zheng et al. 2013; Tang et al. 2018), or reader (Ythdc2) (Hsu et al. 2017; Wojtas et al. 2017) genes have dysfunctions in spermatogenesis that lead to male infertility. This evidence concerns the gene ALKBH5 and male infertility.