To examine this, we tested the effects of challenging A375 cells with IFNα on infection with a wild-type EV with unimpeded eIF4G cleavage and cytotoxicity (Fig. S1A and B) and absent type-I IFN response (coxsackievirus A21 [CAV21] [21]) compared to PVSRIPO (Fig. 2A). Here, EIF4G1 is linked to infection.