In the univariate models (Table 2), participating in the lifestyle treatment (odds ratio [OR] 1.805, p = .008), additional SMS (OR 1.407, p = .077), presence of HA (OR 0.736, p = .105), presence of oligomenorrhea (OR 0.778, p = .181), insulin (OR 0.612, p = .091), cortisol (OR 0.785, p = .199), depression (OR 0.653, p = .062), physical QoL (OR 1.542, p = .081) and mental QoL (OR 1.478, p = .114) had ps < .20 and were therefore included in the multivariable model. The gene discussed is INS; the disease is major depressive disorder.