Besides current underlying mechanism we have proposed (Figure 8), we also note there may be an alternative mechanism that CU27 dually targets tumor suppressor p53 (or p53‐Nupr1complex[48]) and c‐Myc, as well as Sheela A Abraham et al reported in leukemia stem cells.[49] This may lead to synergistic effects of cell target, differentiation, and elimination of CSC at molecular level. The gene discussed is TP53; the disease is leukemia.