Among these ones, it is reported that p53,[30, 31] CDKN2A‐encoded tumor suppressor p14ARF in human,[31] the forkhead box O3 (FoxO3)[32] are negatively regulated in cancers by c‐Myc, a well‐known oncogenic transcription factors in CSCs;[33] and the forkhead box M1 (FoxM1) is negatively by p53.[34] These pieces of molecular regulation evidence indicated that c‐Myc might be a central hub regulator in CU27‐triggered change of gene profiling. The gene discussed is FOXO3; the disease is cancer.