The nanodiscs released DOX in the acidic endosomes of tumor cells to avoid the off‐target side effects.[6c] ICD was successfully induced by released DOX from sHDL‐DOX, which was evidenced with a high level of CRT expressed on the tumor cell surface and robustly released HMGB1.Thus, the frequency of IFN‐γ+ CD8a+ T cells in CT26 tumor‐bearing mice was sevenfold higher than that in the free DOX treatment group. Here, CD8A is linked to neoplasm.