Both therapies resulted in damaged cell membranes and fragmented double strands of DNA, inducing inflammation and antigen release.[171] Treatment with IDOi@nMOF under low‐dose X‐ray irradiation resulted in a significantly higher number of tumor‐infiltrating cytotoxic CD8+ T cells and a competent level of inhibition of the catabolism of tryptophan to kynurenine to alleviate T cells exhaustion, which led to an excellent antitumor effect in multi‐tumor models including glioblastoma, head and neck squamous cell carcinoma, prostate and colorectal tumor. The gene discussed is CD8A; the disease is neoplasm.