In addition, hypoxia modifies the metabolic pathways in the tumor microenvironment and tumor cells obtain energy through glycolysis rather than oxidative phosphorylation.[133] Glycolysis leads to production of lactate that can activate the G‐protein‐coupled receptor GPR81 to suppress innate and adaptive immune cells (NK cells and cytolytic T cells).[134] Blocking the oncogene c‐Myc that is involved in regulation of tumor glycolysis is a promising choice for alleviation of immunosuppression.[135]Sun et al. constructed a supramolecular prodrug nanoplatform via host‐guest complexation. The gene discussed is MYC; the disease is neoplasm.