They injected the ICD inducer DOX into a solid tumor to generate immunogenic apoptotic fragments or debris, then CpG conjugated with cholesterol was injected into the tumor which specifically targeted the tumor cell membrane.[97] In vivo studies revealed that the synergistic treatment delayed tumor growth and elevated the level of CD4+ and CD8+ T cells in CT26 tumor‐bearing mice. Here, CD4 is linked to neoplasm.