After intravenous injection, chain reaction was induced in tumors sites: CuS NPs‐mediated PTT induced ICD to generate antigens and DAMPs (e.g., HSP 70) (Figure 8g) that activated the downstream immune response; R848 and AUNP‐12 remodeled the tumor immune microenvironment to promote DCs maturation, increased the ratio of CD3+CD8+ CTLs tenfold and enhanced secretion of cytokines like TNF‐α and IFN‐γ. This evidence concerns the gene TNF and neoplasm.