This treatment not only significantly increased tumor‐infiltrating leukocytes, DCs and macrophages, but also increased the ratio of M1 to M2 macrophages, which significantly enhanced the treatment effect to eradicate tumors with a tumor growth inhibition rate of 98.2% and a cure rate of 50%.[172] In addition, cooperative treatment of CT26 colorectal tumor‐bearing mice with IMD@Hf‐DBP/αCD47 and an anti‐PD‐L1 immune checkpoint inhibitor led to complete ablation of both primary and distant tumors (Figure 10f,g). Here, CD274 is linked to neoplasm.