MMP2 and neoplasm: By rationally designing responsive NDDSs for synchronous delivery of multiple therapeutic agents with different mechanisms, synergistic multi‐modality therapies including chemotherapy and PDT enable reducing the drug dosage to avoid tumor resistance and metastasis with low/no toxicity.[186, 187, 191] Zhou et al. designed an acidity and MMP‐2‐responsive vesicle (MPV‐HOAD) to load an OXA prodrug and a PEGylated photosensitizer (Figure 13a).