CD274 and neoplasm: Chemotherapeutic agents may up‐regulate immunosuppressive molecules such as PD‐L1 and CD 47 to suppress T cells responses.[80] Biomaterials‐based smart NDDSs can achieve deep tumor penetration with a changeable size, improve tumor cellular uptake with a switchable surface charge, and avoid side effects with target‐responsive release in tumor cells to promote the ICD effect.