IFNG and neoplasm: DOX was conjugated onto PLGA via a pH sensitive hydrazone bond as a core of TSNs and IFN‐γ was adsorbed onto the shell of TSNs via electrostatic interaction.[92] In this delivery system, the size of TSNs was adjustable in response to temperature and it decreased from 100.5 ± 6.3 nm at 25 °C to 89.5 ± 4.0 nm at 37 °C, achieving excellent accumulation in the tumor site in vivo via the EPR effect.