The surface charge could be switched from negative to positive after striping the PEG corona in responsive to MMP‐2 in the tumor site (Figure 13b), facilitating internalization of vesicles into deep tumor cells.[182] Upon laser illumination, both ROS generated from PDT and OXA instantaneously released from the vesicle triggered ICD, which in turn was accompanied with CRT exposure and IFN‐γ secretion (Figure 13c,d). This evidence concerns the gene IFNG and neoplasm.