CD274 and neoplasm: Furthermore, combination of DOX‐induced ICD for increasing specific T cells in the tumor microenvironment and anti‐PD‐1 antibodies dually blocked the PD‐1/PD‐L1 immune escape axis, which indicated that the multifunctional nanoplatform with tumor microenvironment‐mediation ability could contribute to the synergic antitumor effect.[83] In addition, DOX and siRNA such as miR‐200c were combined to down‐regulate the expression of PD‐L1 in tumor cells, exhibiting excellent tumor growth inhibition whilst promoting antitumor immune responses.[98, 99, 100]