For example, nano‐sized metal‐organic frameworks (nMOFs) constructed from Fe3O clusters and a ligand of 5,10,15,20‐tetra(p‐benzoato) porphyrin (TBP), which disintegrated H2O2 to O2 through a Fenton‐like reaction under irradiation to address the issue of hypoxia.[132] The results exhibited that the nMOFs alleviated tumor hypoxia by directly generating O2 and indirectly down‐regulating HIF‐1α protein expression. Here, HIF1A is linked to neoplasm.