CD8A and neoplasm: The tumor cells can be ablated at a temperature of 41–48 °C through damaging DNA, denaturing proteins and disrupting the cellular membrane,[143] which result in release of tumor‐associated antigens and HSPs as “danger signals”.[144] APCs recognize HSPs and present HSPs‐chaperoned peptides to CD8+ T cells, which activate the adaptive immunity.[145] However, PTT alone cannot be effective in ablating distal and metastasizing tumors due to a short tissue penetration depth of the laser source[146] and suboptimal immune activation.