It has been reported that the PI3K/Akt pathway plays a crucial role in various biological processes, including cancer,[37] pain,[38] and nerve regeneration.[39] It has also been implicated in pathophysiological processes induced by Mg‐based biomaterials.[40] Our results validated that the PI3K/Akt signaling pathway plays a role in Mg‐induced neurite outgrowth, as axonal growth density and length were significantly inhibited by the PI3K/Akt inhibitor LY294002. The gene discussed is AKT1; the disease is cancer.